Molecular characterization of avian pathogenic Escherichia coli strains in Jiangxi Province, China, and development of polyvalent inactivated vaccines.

ABSTRACT: Avian pathogen Escherichia coli (APEC) poses a significant threat to poultry farming, causing colibacillosis in various hosts, including chickens, ducks, geese, and pigeons. This study aimed to investigate the molecular epidemiology of APEC in Jiangxi Province, China, to inform prevention and control strategies. Between 2020 and 2024, 186 APEC strains were isolated and identified, with 88.7 % from liver samples and 5.4 % from brain tissues. Whole-genome sequencing and analysis revealed that serotypes O145, O78, O8, and O111 comprised 32.9 %, 9.3 %, 7.9 %, and 4.3 % of the isolates, respectively. The dominant H serotypes included H21 (23.8 %), H9 (22.7 %), and H4 (18.2 %), with ST23 being the most prevalent sequence type at 24.2 %, followed by ST117 (10.1 %) and ST2505 (7.3 %). Virulence-as

SUBMITTER: Tan J 

PROVIDER: S-EPMC11757759 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature