Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control.

ABSTRACT:

Background

Irritability affects up to 20% of youth and is a primary reason for referral to pediatric mental health clinics. Irritability is thought to be associated with disruptions in processing of reward, threat, and cognitive control; however, empirical study of these associations at both the behavioral and neural level have yielded equivocal findings that may be driven by small sample sizes and differences in study design. Associations between irritability and brain connectivity between cognitive control and reward- or threat-processing circuits remain understudied. Furthermore, better inhibitory control has been linked to lower irritability and differential neural functioning among irritable youth, suggesting that good inhibitory control may serve as a protective factor.

Me

SUBMITTER: DeSerisy M 

PROVIDER: S-EPMC11758128 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature