Inflammatory proteins related to depression in multiple sclerosis: A systematic review and meta-analysis.

ABSTRACT:

Background

Up to 50% of individuals with multiple sclerosis (MS) experience depression. Depression has been accompanied by increases in inflammatory proteins. This meta-analysis summarized the data on inflammatory protein concentrations and level of depression in individuals with MS.

Methods

We performed a meta-analysis of studies measuring inflammatory protein concentrations and level of depression in individuals with MS with a database search of the English literature (to October 2024) and a manual search of references. Quality of evidence was also assessed.

Results

Fifteen studies involving measurements of inflammatory proteins and level of depression in 1102 individuals with MS were included in the meta-analysis: five for interleukin (IL)-10 (LPS and PHA), four fo

SUBMITTER: Kiropoulos LA 

PROVIDER: S-EPMC11758135 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature