Oxidative stress in critically ill neonatal foals.

ABSTRACT:

Background

Oxidative injury occurs in septic people, but the role of oxidative stress and antioxidants has rarely been evaluated in foals.

Objectives/hypothesis

To measure reactive oxygen species (ROS), biomarkers of oxidative injury, and antioxidants in neonatal foals. We hypothesized that ill foals would have higher blood concentrations of ROS and biomarkers of oxidative injury and lower concentrations of antioxidants compared to healthy foals.

Animals

Seventy-two hospitalized and 21 healthy neonatal foals.

Methods

Prospective cohort study. Reactive oxygen species (hydrogen peroxide [H₂O₂]), biomarkers of oxidative injury (malondialdehyde [MDA], protein carbonyl), and antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione,

SUBMITTER: Wong D 

PROVIDER: S-EPMC11758150 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature