Comparative transcriptome analysis reveals a serotype-specific immune response in Nile tilapia (<i>Oreochromis niloticus</i>) infected with <i>Streptococcus agalactiae</i>.

ABSTRACT: Streptococcus agalactiae is a major causative agent of streptococcosis in Nile tilapia (Oreochromis niloticus) and understanding its etiology is important to ensure the sustainable development of global tilapia farming. Our research group recently observed contrasting disease patterns in animals infected with two different S. agalactiae serotypes (Ib and III). To better understand the basis for these divergent responses, we analyzed the brain transcriptome of Nile tilapia following bacterial exposure. Our findings revealed significant variation in the expression of genes involved in immune (e.g., CD209 antigen, granulin, C-X-C motif chemokine 10, prostacyclin synthase, and interleukins) and neuroendocrine (e.g., mmp13a, mmp9, brain aromat

SUBMITTER: Appel RJC 

PROVIDER: S-EPMC11758187 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature