The temporal relationship between mitochondrial quality and renal tissue recovery following ischemia-reperfusion injury.

ABSTRACT:

Background

Growing evidence indicates that disruptions in mitochondrial quality management contribute to the development of acute kidney injury (AKI), incomplete or maladaptive kidney repair, and chronic kidney disease. However, the temporal dynamics of mitochondrial quality control alterations in relation to renal injury and its recovery remain poorly understood and are addressed in this manuscript.

Method

ology: Male Wistar rats (n = 60) were subjected to varying durations of ischemia and reperfusion. Ischemia was instigated by clamping both renal arteries and for reperfusion, the clamps were removed to restore the blood flow. Renal injury, physiological function, mitochondrial assessment, and cellular mediators were analyzed.

Results

Prolonging ischemia duration re

SUBMITTER: Prem PN 

PROVIDER: S-EPMC11758212 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature