A Parallel Human and Rat Investigation of the Interaction Between Descending and Spinal Modulatory Mechanisms.

ABSTRACT:

Background

Healthy individuals demonstrate considerable heterogeneity upon dynamic quantitative sensory testing assessment of endogenous pain modulatory mechanisms. For those who stratify into a 'pro-nociceptive profile' cohort, consisting of inefficient conditioned pain modulation (CPM) and elevated temporal summation of pain (TSP), the optimal approach for balancing the net output of pain modulatory processes towards anti-nociception remains unresolved. In this translational healthy human and rat study, we examined whether descending modulation countered spinal amplification during concurrent application of a CPM and TSP paradigm alongside pupillometry since pontine activity was previously linked to functionality of endogenous pain modulatory mechanisms and pupil dilation.

Met

SUBMITTER: Fieldwalker A 

PROVIDER: S-EPMC11758248 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature