Asymmetric Three-Component Radical Cascade Reactions Enabled by Synergistic Photoredox/Bronsted Acid Catalysis: Access to α-Amino Acid Derivatives.

ABSTRACT: Multicomponent reactions (MCRs), highly sought-after methods to produce atom-, step-, and energy-economic organic syntheses, have been developed extensively. However, catalytic asymmetric MCRs, especially those involving radical species, remain largely unexplored owing to the difficulty in stereoselectively regulating the extraordinarily high reactivity of open-shell radical species. Herein, we report a conceptually novel catalytic asymmetric three-component radical cascade reaction of readily accessible glycine esters, α-bromo carbonyl compounds and 2-vinylcyclopropyl ketones via synergistic photoredox/Brønsted acid catalysis, in which three sequential C-C (σ/π/σ) bond-forming events occurred through a radical addition/ring-opening/radical-radical coupling protocol, affording an array of

SUBMITTER: Che C 

PROVIDER: S-EPMC11758273 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature