An archaeal antioxidant: characterization of a Dps-like protein from Sulfolobus solfataricus.

ABSTRACT: Evolution of an oxygenic atmosphere required primordial life to accommodate the toxicity associated with reactive oxygen species. We have characterized an archaeal antioxidant from the hyperthermophilic acidophile Sulfolobus solfataricus. The amino acid sequence of this approximately 22-kDa protein shares little sequence similarity with proteins with known function. However, the protein shares high sequence similarity with hypothetical proteins in other archaeal and bacterial genomes. Nine of these hypothetical proteins form a monophyletic cluster within the broad superfamily of ferritin-like diiron-carboxylate proteins. Higher order structural predictions and image reconstructions indicate that the S. solfataricus protein is structurally related to a class of DNA-binding protein from star

SUBMITTER: Wiedenheft B 

PROVIDER: S-EPMC1175829 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature