Auditory sensory processing measures using EEG and MEG predict symptom recovery in first-episode psychosis with a single-tone paradigm.

ABSTRACT: Predicting symptom progression in first-episode psychosis (FEP) is crucial for tailoring treatment and improving outcomes. Temporal lobe function, indicated by neurophysiological biomarkers like N100, predicts symptom progression and correlates with untreated psychosis. Our recent report showed that source-localized magnetoencephalography (MEG) M100 responses to tones in an oddball paradigm predicted recovery in FEP positive symptoms. This study expands these results with a simpler single-tone paradigm, with both MEG and EEG, and measuring associations across symptom dimensions. We recorded MEG (M100) and EEG (N100) in 29 FEP individuals and assessed symptom severity at baseline and after ∼ 7 months using the Positive and Negative Syndrome Scale (PANSS). Sequential regression analyses pred

SUBMITTER: Lopez-Caballero F 

PROVIDER: S-EPMC11758393 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature