A Cost-Effective Two-Step Approach for Multi-Cancer Early Detection in High-Risk Populations.

ABSTRACT:

Significance

Large-scale screening inevitably leads to significant financial burdens on the healthcare system, which is a key factor constraining nationwide screenings. The two-step MCED approach not only maintains comparable performance but also substantially alleviates financial strains compared with the direct use of next-generation sequencing-based MCED tests for massive screenings.

SUBMITTER: Geng S 

PROVIDER: S-EPMC11758400 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature