Humoral and cellular response to SARS-CoV-2 mRNA vaccine in paediatric heart transplant recipients.

ABSTRACT:

Objective

The aim of this prospective cohort study is to analyse the humoral and cellular vaccine responses in paediatric heart transplant recipients (HTR, n = 12), and compare it with the response in healthy controls (HC, n = 14). All participants were 5-18 years old and vaccinated with mRNA vaccine against SARS-CoV-2 between December 2021 and May 2022.

Methods

The humoral response was measured by quantifying antibody titers against SARS-CoV-2 spike protein (anti-S). The T-lymphocyte phenotype and SARS-CoV2-specific CD4⁺ and CD8⁺ T-cell response was studied by multiparametric flow cytometry through peripheral blood mononuclear cells by the quantification of degranulation markers (CD107a) and intracellular cytokines (IFN-γ, TNF-α and IL-2) after in v

SUBMITTER: Bermejo-Gomez A 

PROVIDER: S-EPMC11758410 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature