Shearinines U-Y, indole diterpenoids from an entomogenous fungus, Penicillium sp.

ABSTRACT: Five new indole diterpenoids, shearinines U-Y (2-6), and the known compound 22,23-dehydro-shearinine A (1) were isolated from cultures of the entomogenous fungus Penicillium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 2-6 were assigned by electronic circular dichroism calculations, respectively. Compounds 1-3 showed moderate cytotoxicity, with IC₅₀ values of 11.7-26.2 μM.

SUBMITTER: Fu P 

PROVIDER: S-EPMC11758498 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature