The role of energy deposition on the luminescence sensitization in porphyrin-functionalized SiO₂/ZnO nanoparticles under X-ray excitation.

ABSTRACT: Hybrid nanoscintillators, which feature a heavy inorganic nanoparticle conjugated with an organic emitter, represent a promising avenue for advancements in diverse fields, including high-energy physics, homeland security, and biomedicine. Many research studies have shown the suitability of hybrid nanoscintillators for radiation oncology, showing potential to improve therapeutic results compared to traditional protocols. In this work, we studied SiO₂/ZnO nanoparticles functionalized with porphyrin as a photosensitizer, capable of producing cancer cytotoxic reactive oxygen species for possible use in radio-oncological therapeutics. Radioluminescence measurements under increasing energy of the ionizing radiation beam up to 10 keV show sensitization of porphyrin moieties on SiO

SUBMITTER: Villa I 

PROVIDER: S-EPMC11758577 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature