Linking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer.

ABSTRACT:

Background

The infiltration of tumor-infiltrating B cells and plasma cells in early-stage breast cancer has been associated with a reduced risk of distant metastasis. However, the influence of B-cell tumor infiltration on overall patient survival remains unclear.

Materials and methods

This study explored the relationship between an antitumor immune response, measured by a 14-gene B-cell/immunoglobulin (IGG) signature, and mortality risk in 9638 breast cancer patients across three datasets. Associations with tumor subtype, stage, and age were examined. IGG was characterized using spatial GeoMx profiling and single-cell RNA sequencing, and its relationship with tertiary lymphoid structures (TLSs) was evaluated. The predictive value of each of the 14 IGG genes for B-cell recept

SUBMITTER: Angelats L 

PROVIDER: S-EPMC11758579 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature