Investigating the potential of diffusion tensor atlases to generate anisotropic clinical tumor volumes in glioblastoma patients.

ABSTRACT:

Background and purpose

Diffusion tensor imaging (DTI) has been proposed to guide the anisotropic expansion from gross tumor volume to clinical target volume (CTV), aiming to integrate known tumor spread patterns into the CTV. This study investigate the potential of using a DTI atlas as an alternative to patient-specific DTI for generating anisotropic CTVs.

Materials and methods

The dataset consisted of twenty-eight newly diagnosed glioblastoma patients from a Danish national DTI protocol with post-operative T1-contrast and DTI imaging. Three different DTI atlases, spatially aligned to the patient images using deformable image registration, were considered as alternatives. Anisotropic CTVs were constructed to match the volume of a 15 mm isotropic expansion by generating 3D di

SUBMITTER: Hochreuter K 

PROVIDER: S-EPMC11758580 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature