An animal model of severe acute respiratory distress syndrome for translational research.

ABSTRACT:

Background

Despite the fact that an increasing number of studies have focused on developing therapies for acute lung injury, managing acute respiratory distress syndrome (ARDS) remains a challenge in intensive care medicine. Whether the pathology of animal models with acute lung injury in prior studies differed from clinical symptoms of ARDS, resulting in questionable management for human ARDS. To evaluate precisely the therapeutic effect of transplanted stem cells or medications on acute lung injury, we developed an animal model of severe ARDS with lower lung function, capable of keeping the experimental animals survive with consistent reproducibility. Establishing this animal model could help develop the treatment of ARDS with higher efficiency.

Results

In this approach, w

SUBMITTER: Chu KA 

PROVIDER: S-EPMC11758736 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature