FPR1 affects acute rejection in kidney transplantation by regulating iron metabolism in neutrophils.

ABSTRACT:

Background

Acute rejection (AR) is one of the significant factors contributing to poor prognosis in patients following kidney transplantation. Neutrophils are the main cause of early host-induced tissue injury. This paper intends to investigate the possible mechanisms of neutrophil involvement in acute rejection in renal transplantation.

Methods

Samples were analyzed for their relationship with immune cells using CIBERSORT. WGCNA was used to identify modules with high relevance to neutrophils and hub genes in the modules were extracted. The effect on neutrophil function after blocking formyl peptide receptor 1 (FPR1) was tested in vitro experiments. The effects of blocking FPR1 on neutrophil function as well as acute rejection were tested in vivo after constructing a mouse k

SUBMITTER: Li P 

PROVIDER: S-EPMC11758745 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature