Spirometry Versus Forced Oscillation to Assess Lung Function Outcome at 5 Years of Age.

ABSTRACT:

Background

Spirometry is the gold standard for assessing airway function for clinical studies; however, obtaining high-quality data in young children remains challenging. Since the forced oscillation technique (FOT) requires less subject cooperations, there has been increasing interest in FOT, particularly in young children. We evaluated whether spirometry and FOT in young children provides comparable ability to detect a treatment effect.

Methods

We recently reported in a randomized controlled trial that vitamin C compared to placebo treatment of mothers who smoked during pregnancy (MSDP) results in the offspring having significantly higher forced expiratory flows (FEFs) at 5-years of age, as well as significantly less wheeze at 4-6 years of age. In these same offspring, we

SUBMITTER: Tepper RS 

PROVIDER: S-EPMC11758767 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature