Clinical impact of inappropriate DOAC dosing in atrial fibrillation: Insights from a real-world registry.

ABSTRACT:

Background

A significant number of patients with atrial fibrillation (AF) on direct oral anticoagulants (DOACs) receives off-label or inappropriate doses. This study examines the prevalence, dosages, and clinical outcomes in AF-patients on DOAC therapy admitted to an emergency department (ED).

Methods

This retrospective single-center observational study utilized data from the Heidelberg Registry of Atrial Fibrillation (HERA-FIB), consecutively including patients with AF presenting to the ED of the University Hospital of Heidelberg from June 2009 to March 2020. Rates of DOAC dosages at discharge from the ED were correlated with outcomes, focusing on a composite endpoint that included all-cause mortality, stroke, major bleeding, and myocardial infarction (MI).

Resultsand co

SUBMITTER: Yildirim M 

PROVIDER: S-EPMC11758832 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature