Progesterone Receptor Activation Regulates Sensory Sensitivity and Migraine Susceptibility.

ABSTRACT: Women develop chronic pain during their reproductive years more often than men, and estrogen and progesterone regulate this susceptibility. We tested whether brain progesterone receptor (PR) signaling regulates pain susceptibility. During the estrous cycle, animals were more sensitive to mechanical stimulus during the estrus stage than in the diestrus stage, suggesting a role for reproductive hormones, estrogen, and progesterone. Progesterone treatment of ovariectomized and estrogen-primed mice caused a delayed reduction in the mechanical threshold. Segesterone, a specific agonist of PRs replicated this effect, whereas, the segesterone-induced reduction in mechanical threshold was blocked in the mice lacking PRs in the nervous system. Segesterone treatment also did not alter mechanical thr

SUBMITTER: Joshi S 

PROVIDER: S-EPMC11758909 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature