Melatonin attenuates MPP⁺-induced autophagy <i>via</i> heat shock protein in the Parkinson's disease mouse model.

ABSTRACT:

Background

This study investigates the protective properties of melatonin in an in vivo Parkinson's disease (PD) model, focusing on the underlying mechanisms involving heat shock proteins (HSPs).

Methods

Twelve adult male C57BL/6 mice were randomly divided into four groups (normal control, melatonin control, Parkinson's model, and melatonin treatment; n = 3 per group) and housed in a single cage. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was injected intraperitoneally in the Parkinson's model and treatment groups to establish a subacute PD model, while controls received saline. Limb motor ability was assessed 1 h after the final injection using behavioral tests, including the open field test to evaluate central zone entries and average movement. Dopam

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11758912 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature