Spatial chromosome organization and adaptation of the radiation-resistant extremophile Deinococcus radiodurans.

ABSTRACT: Radiation-resistant Deinococcus radiodurans is an extremophilic microorganism capable of withstanding high levels of ionizing radiation and chemical mutagens. It possesses remarkable DNA repair capability and serves as a model organism for studying stress resistance mechanisms. However, our understanding of the spatial chromosome organization of this species remains limited. In this study, we employed chromosome conformation capture (3C) technology to determine the 3D genome structure of D. radiodurans and to further investigate the changes of chromosome conformation induced by ultraviolet (UV) irradiation. We observed that UV irradiation reduced short-range chromosome interactions, and smaller chromosomal interaction domains (CIDs) merged to form larger CIDs. Integrating transcriptomic da

SUBMITTER: Qiu QT 

PROVIDER: S-EPMC11758949 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature