COVID-19 related epigenetic changes and atopic dermatitis: An exploratory analysis.

ABSTRACT:

Background

While epidemiological data suggest a connection between atopic dermatitis (AD) and COVID-19, the molecular mechanisms underlying this relationship remain unclear.

Objective

To investigate whether COVID-19-related CpGs may contribute to AD development and whether this association is mediated through the regulation of specific genes' expression.

Methods

We combined Mendelian randomization and transcriptome analysis for data-driven explorations.

Results

Among the 172 CpGs -associated with COVID-19 infection, merely 3 of them exhibited significant impacts on the risk of AD, including cg04543273, cg11916609, and cg10636246. In the following analysis of the causal effects of CpGs and their related gene expression, cg04543273 inhibited LMAN2 expression. How

SUBMITTER: Tang Z 

PROVIDER: S-EPMC11758953 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature