Contagious acquisition of antimicrobial resistance is critical for explaining emergence in western Canadian feedlots-insights from an agent-based modelling tool.

ABSTRACT:

Introduction

Antimicrobial resistance (AMR) is a growing threat to the efficacy of antimicrobials in humans and animals, including those used to control bovine respiratory disease (BRD) in high-risk calves entering western Canadian feedlots. Successful mitigation strategies require an improved understanding of the epidemiology of AMR. Specifically, the relative contributions of antimicrobial use (AMU) and contagious transmission to AMR emergence in animal populations are unknown.

Materials and methods

A stochastic, continuous-time agent-based model (ABM) was developed to explore the dynamics of population-level AMR in Mannheimia haemolytica in pens of high-risk cattle on a typical western Canadian feedlot. The model was directly informed and parameterized with proprie

SUBMITTER: Ramsay D 

PROVIDER: S-EPMC11758982 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature