Ambient Toxic Air Contaminants in the Maternal Residential Area during Pregnancy and Cerebral Palsy in the Offspring.

ABSTRACT:

Background

Cerebral palsy (CP) is the most common permanent neuromotor disorder diagnosed in childhood. Although most cases have unknown etiology, emerging evidence suggests environmental risk factors of CP.

Objectives

We investigated whether ambient toxic air contaminants (TACs) in the maternal residential area during pregnancy, specifically volatile organic compounds (VOCs) and metals, were associated with offspring CP risk in California.

Methods

We conducted a case-cohort study that included CP cases (N=906) and a 20% random sample of all live singleton births (N=184,954) who lived within a 5-mile (8-km) radius of air toxics monitoring stations in California during 2005-2015 as the control comparison group. CP cases were ascertained from diagnostic records of the C

SUBMITTER: Zhuo H 

PROVIDER: S-EPMC11758984 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature