Prefrontal tDCS fails to modulate memory retrieval in younger and older adults.

ABSTRACT: Previous research shows that a single session of anodal transcranial direct current stimulation (tDCS) to the left dorsolateral prefrontal cortex (dlPFC) can improve the accuracy of episodic memory retrieval, but stimulation effects are not always found and may be moderated by time of day. Here, we report the results from a rigorous clinical trial (NCT03723850) designed to replicate these tDCS findings in younger adults and extend them to cognitively normal older adults. We conducted the largest double-blind, between-subjects tDCS study on memory retrieval in younger and older adults to date. 150 younger adults and 91 older adults received anodal tDCS or sham stimulation to the left dlPFC prior to episodic memory retrieval and working memory tasks. We also manipulated when tDCS was adminis

SUBMITTER: Arar T 

PROVIDER: S-EPMC11759060 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature