Omics-Based Interaction Analysis Reveals Interplay of Chemical Pollutant (Ozone) and Photoradiation (UVSSR) Stressors in Skin Damage.

ABSTRACT: The skin acts as the first line of defense against various environmental stressors, such as solar ultraviolet radiation, visible light, pollution particles and ozone. Simultaneous exposure to different stressors is common in everyday life but has been less studied than exposure to single stressors. Herein, the combined effects of a chemical pollutant (ozone) and a UV radiation stressor (UVSSR) were investigated on a 3D pigmented living skin equivalent model. Our results demonstrate that skin lightness (L* value) was significantly decreased by exposure to either UVSSR or ozone alone and that co-exposure to UVSSR and ozone further exacerbated surface darkness, suggesting that these stressors had a significant joint effect. Conventional differential expression analysis showed that, among expo

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11759167 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature