Fingolimod and risk of skin cancer among individuals with multiple sclerosis: a population-based cohort study protocol.

ABSTRACT:

Introduction

Long-term population-based safety studies, applying advanced causal inference techniques, including an active comparator with new-user design, are needed to investigate skin cancer outcomes among individuals with multiple sclerosis (MS) treated with fingolimod. This study aims to describe a protocol for investigating the relationship between fingolimod use and the incidence of skin cancer among individuals with MS.

Methods and analysis

We will use population-based administrative health data from two Canadian provinces (British Columbia and Alberta) to conduct an observational cohort 'trial emulation' study with an active comparator and new-user design. Individuals with MS aged ≥18 years will be identified using a validated algorithm. Incident users of fingolimod

SUBMITTER: Jia A 

PROVIDER: S-EPMC11759199 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature