DiscoDivas: Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations.

ABSTRACT: The relatively low representation of admixed populations in both discovery and fine-tuning individual-level datasets limits polygenic risk score (PRS) development and equitable clinical translation for admixed populations. Under the assumption that the most informative PRS model for a genetically homogeneous sample varies linearly in an ancestry continuum space, we introduce a Genetic Distance-assisted PRS Combination Pipeline for Diverse Genetic Ancestries (DiscoDivas) to interpolate a harmonized PRS for diverse, especially admixed, genetic ancestries, leveraging multiple PRS models fine-tuned within existing samples, which are mostly of single ancestry, and genetic distance. DiscoDivas treats genetic ancestry as a continuous variable and does not

SUBMITTER: Ruan Y 

PROVIDER: S-EPMC11759244 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature