An injectable, self-healing, anti-infective, and anti-inflammatory novel glycyrrhizic acid hydrogel for promoting acute wound healing and regeneration.

ABSTRACT:

Introduction

Bacterial infection, a complex wound microenvironment, and a persistent inflammatory response in acute wounds can result in delayed healing and abnormal scar formation, thereby compromising the normal function and aesthetic appearance of skin tissue. This issue represents one of the most challenging problems in clinical practice. This study aims to develop a hydrogel dressing specifically designed for the treatment of acute wounds, providing immediate and effective protection for the affected areas. This innovation seeks to offer a novel and advanced solution for the management of acute wounds.

Methods

In this study, a composite hydrogel scaffold was synthesized through the reaction between oxidized glycyrrhizic acid and carboxymethyl chitosan Schiff base. The m

SUBMITTER: Guo Q 

PROVIDER: S-EPMC11759265 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature