Retinal biomarkers for the risk of Alzheimer's disease and frontotemporal dementia.

ABSTRACT:

Purpose

Differentiating between Alzheimer's disease (AD) and frontotemporal dementia (FTD) can be challenging due to overlapping cognitive and behavioral manifestations. Evidence regarding non-invasive and early-stage biomarkers remains limited. Our aim was to identify retinal biomarkers for the risk of AD and FTD in populations without dementia and explore underlying brain structural mechanisms.

Methods

We included a total of 3,0573 UK Biobank participants without dementia, ocular disorders, and diabetes who underwent baseline retinal optical coherence tomography (OCT) imaging. Cox proportional hazards models were used to estimate the associations between macular OCT parameters and the risk of AD and FTD. Mediation analysis was used to explore the underlying mechanisms affe

SUBMITTER: Wang R 

PROVIDER: S-EPMC11759267 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature