Pan-cancer analysis of Arp2/3 complex subunits: focusing on ARPC1A's role and validating the ARPC1A/c-Myc axis in non-small cell lung cancer.

ABSTRACT:

Background

The Arp2/3 complex is a key regulator of tumor metastasis, and targeting its subunits offers potential for anti-metastatic therapy. However, the expression profiles, prognostic relevance, and diagnostic value of its subunits across cancers remain poorly understood. This study aims to investigate the clinical relevance of Arp2/3 complex subunits, particularly ARPC1A, in pan-cancer, and to further analyze the potential biological mechanisms of ARPC1A, as well as its association with immune infiltration and chemotherapy drug sensitivity.

Methods

To explore the differential expression of Arp2/3 complex subunits and their clinical relevance across cancers, we analyzed data from TCGA and GTEx databases. The relationship between ARPC1A and immune infiltration, as well as

SUBMITTER: Zhou C 

PROVIDER: S-EPMC11759278 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature