A novel muscle network approach for objective assessment and profiling of bulbar involvement in ALS.

ABSTRACT:

Introduction

As a hallmark feature of amyotrophic lateral sclerosis (ALS), bulbar involvement significantly impacts psychosocial, emotional, and physical health. A validated objective marker is however lacking to characterize and phenotype bulbar involvement, positing a major barrier to early detection, progress monitoring, and tailored care. This study aimed to bridge this gap by constructing a multiplex functional mandibular muscle network to provide a novel objective measurement tool of bulbar involvement.

Methods

A noninvasive electrophysiological technique-surface electromyography-was combined with graph network analysis to extract 48 features measuring the regulatory mechanisms, connectivity, integration, segregation, assortativity, and lateralization of the functional

SUBMITTER: Rong P 

PROVIDER: S-EPMC11759300 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature