Development of a multi-epitope chimeric vaccine in silico against Babesia bovis, Theileria annulata, and Anaplasma marginale using computational biology tools and reverse vaccinology approach.

ABSTRACT: The three rickettsial parasites- Babesia bovis, Theileria annulata and Anaplasma Marginale are responsible for causing Babesiosis, Theileriosis and Anaplasmosis among cattle. These diseases exist due to spreading of infected ticks. A large number of cattle were found to suffer from mixed infections caused by the three parasites at the same time. Due to these reasons cattle have been devoid of milk production with reduced meat availability. Hence, it is a matter of urgency for the immunity of cattle to exhibit resilience against all three rickettsial parasites. It could be possible if trials are carried out after producing a subunit chimeric vaccine against the rickettsial protozoan parasites and introducing it into the bloodstream of the cattle species. In this paper, we have used the proc

SUBMITTER: Siddiki AZ 

PROVIDER: S-EPMC11759392 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature