Detection and analysis of Serpin and RP26 specific antibodies for monitoring Schistosoma haematobium transmission.

ABSTRACT:

Background

Schistosoma haematobium is the causative pathogen for urogenital schistosomiasis. To achieve progress towards schistosomiasis elimination, there is a critical need for developing highly sensitive and specific tools to monitor transmission in near-elimination settings. Although antibody detection is a promising approach, it is usually unable to discriminate active infections from past ones. Moreover, crude antigens such as soluble egg antigen (SEA) show cross-reactivity with other parasitic infections, and it is difficult to formulate the standard preparations. To resolve these issues, the performances of recombinant antigens have been evaluated. The antibody responses against recombinant S. haematobium serine-protease inhibitor (ShSerpin) and RP26 were previously shown t

SUBMITTER: Kokubo-Tanaka M 

PROVIDER: S-EPMC11759395 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature