Dynamics and regulatory roles of RNA m⁶A methylation in unbalanced genomes.

ABSTRACT: N⁶-methyladenosine (m⁶A) in eukaryotic RNA is an epigenetic modification that is critical for RNA metabolism, gene expression regulation, and the development of organisms. Aberrant expression of m⁶A components appears in a variety of human diseases. RNA m⁶A modification in Drosophila has proven to be involved in sex determination regulated by Sxl and may affect X chromosome expression through the MSL complex. The dosage-related effects under the condition of genomic imbalance (i.e. aneuploidy) are related to various epigenetic regulatory mechanisms. Here, we investigated the roles of RNA m⁶A modification in unbalanced genomes using aneuploid Drosophila. The results showed that the expression of m⁶

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11759410 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature