Prevalence of obsessive-compulsive symptoms in patients with schizophrenia treated with clozapine: a scoping review.

ABSTRACT:

Background

Schizophrenia is a complex psychiatric disorder, and in patients treated with clozapine, it may induce or exacerbate obsessive-compulsive symptoms (OCS), which negatively affect patients' quality of life, functionality and treatment adherence. Despite its clinical relevance, the reported prevalence and characteristics of clozapine associated OCS vary widely, limiting effective management.

Objective

This scoping review synthesizes evidence on the prevalence of OCS in patients with schizophrenia treated with clozapine and explores treatment characteristics (types, severity, dose, and time to onset/exacerbation).

Methods

The PRISMA-ScR methodology guided the search in PubMed, LILACS, Embase, and Scielo. Observational studies in Spanish, English, Portuguese, an

SUBMITTER: Moreno Tarazona E 

PROVIDER: S-EPMC11759428 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature