Tear metabolomics reveals novel potential biomarkers in epithelial herpes simplex keratitis.

ABSTRACT:

Background

Herpes simplex keratitis (HSK) is a recurrent inflammatory disease of cornea primarily initiated by type I herpes simplex virus infection of corneal epithelium. However, early diagnosis of HSK remains challenging due to the lack of specific biomarkers. This study aims to identify biomarkers for HSK through tear metabolomics analysis between HSK and healthy individuals.

Methods

We conducted a cross-sectional study enrolling 33 participants. Tear samples were collected from one eye of 18 HSK patients and 15 healthy volunteers using Schirmer-strips. Tear metabolomic profiling was performed using high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS). Metabolites were quantified and matched against entries in the human metabolome database (HMDB) an

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11759447 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature