Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation.

ABSTRACT: The family of heterodimeric CD11/CD18 integrins facilitate leukocyte adhesion and migration in a wide range of normal physiologic responses, as well as in the pathology of inflammatory diseases. Soluble CD18 (sCD18) is found mainly in complexes with hydrodynamic radii of 5 and 7.2 nm, suggesting a compositional difference. Earlier work reported that the complexes include at least part of the CD11a or CD11b chains containing the intercellular adhesion molecule (ICAM)-1 binding domain, and that sCD18 is capable of quantitatively competing with the cell membrane-bound form for ICAM-1 binding. However, it is not clear if the size differences between the sCD18 complexes reflect any functional variance regarding shedding from the cell membrane or binding to ICAM-1. Here, we show evidence that sC

SUBMITTER: Ferapontov A 

PROVIDER: S-EPMC11759538 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature