Construction of a novel cuproptosis-related gene signature and integrative analyses in cholangiocarcinoma.

ABSTRACT:

Background

Cuproptosis is a unique form of cell death that is dependent on copper, which is fundamentally different from other recognized forms of cell death. However, the molecular and immune characteristics in cuproptosis-defined subgroups of cholangiocarcinoma (CCA) remain to be further illustrated.

Methods

We conducted a comprehensive investigation into the genetic and transcriptional variation, prognostic significance, and expression profiles of 16 cuproptosis-related genes (CRGs). To construct a prognostic signature based on differentially expressed genes between molecular subtypes, we employed LASSO and multivariate Cox regression analyses. We then assessed the values of this signature in prognostic prediction, immune infiltration, and therapeutic responses in CCA. Th

SUBMITTER: Wang L 

PROVIDER: S-EPMC11759551 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature