Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice.

ABSTRACT: The gut microbiome modulates the anti-seizure effects of the ketogenic diet, but how specific dietary formulations differentially modify the gut microbiome in ways that impact seizure outcome is poorly understood. We find that medical ketogenic infant formulas vary in macronutrient ratio, fat source, and fiber content and differentially promote resistance to 6-Hz seizures in mice. Dietary fiber, rather than fat ratio or source, drives substantial metagenomic shifts in a model human infant microbial community. Addition of fiber to a fiber-deficient ketogenic formula restores seizure resistance, and supplementing protective formulas with excess fiber potentiates seizure resistance. By screening 13 fiber sources and types, we identify metagenomic responses in the model community that correspo

SUBMITTER: Ozcan E 

PROVIDER: S-EPMC11759687 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature