Elucidating distinct and common fMRI-complexity patterns in pre-adolescent children with Attention-Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder, and Obsessive-Compulsive Disorder diagnoses.

ABSTRACT:

Importance

The pathophysiology of ADHD is complicated by high rates of psychiatric comorbidities, thus delineating unique versus shared functional brain perturbations is critical in elucidating illness pathophysiology.

Objective

To investigate resting-state fMRI (rsfMRI)-complexity alterations among children with ADHD, oppositional defiant disorder (ODD), and obsessive-compulsive disorder (OCD), respectively, and comorbid ADHD, ODD, and OCD, within the cool and hot executive function (EF) networks.

Design

We leveraged baseline data (wave 0) from the Adolescent Brain and Cognitive Development (ABCD) Study.

Setting

The data was collected between September 2016 and September 2019 from 21 sites in the USA.

Participants

Children who singularly met all DSM-5 b

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11759830 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature