Genomic analysis of metabolic pathway gene expression in mice.

ABSTRACT:

Background

A segregating population of (C57BL/6J x DBA/2J)F2 intercross mice was studied for obesity-related traits and for global gene expression in liver. Quantitative trait locus analyses were applied to the subcutaneous fat-mass trait and all gene-expression data. These data were then used to identify gene sets that are differentially perturbed in lean and obese mice.

Results

We integrated global gene-expression data with phenotypic and genetic segregation analyses to evaluate metabolic pathways associated with obesity. Using two approaches we identified 13 metabolic pathways whose genes are coordinately regulated in association with obesity. Four genomic regions on chromosomes 3, 6, 16, and 19 were found to control the coordinated expression of these pathways. Using cri

SUBMITTER: Ghazalpour A 

PROVIDER: S-EPMC1175990 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature