Force-bearing phagocytic adhesion rings mediate the phagocytosis of surface-bound particles.

ABSTRACT: Many micro-particles including pathogens strongly adhere to hosts. It remains elusive how macrophages detach these surface-bound particles during phagocytosis. We show that, rather than binding directly to these particles, macrophages form unique β₂ integrin-mediated adhesion structures at the cell-substrate interfaces, specifically encircling the surface-bound particles. These circular adhesion structures that we named phagocytic adhesion rings (PARs) serve as strongholds to support local ring-shaped actin structures constricting into the particle-substrate cleavages, thereby pinching off the particles from the substrate. During this process, integrins in PARs sustain tensions due to the reaction force of actin polymerization against the particles. Such tensions are critical fo

SUBMITTER: Kundu S 

PROVIDER: S-EPMC11759950 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature