Evaluation of the association between lymph node ratio and long-term survival in patients after surgery for lymph node-positive bladder cancer: a SEER population-based study with external validation.

ABSTRACT:

Background

The lymph node ratio (LNR) has been recognized as an emerging prognostic biomarker in various malignant tumors. Our study aimed to investigate the prognostic role of LNR in postoperative patients with lymph node-positive bladder cancer.

Methods

This study comprised a total of 3911 eligible patients diagnosed with lymph node-positive bladder cancer. This included 3767 patients from the Surveillance, Epidemiology, and End Results (SEER) database and 144 patients from two Chinese hospitals forming the external validation cohort. We used X-tile software to identify the optimal cut-off value for LNR. The Kaplan-Meier method and Cox regression model were utilized to evaluate the association between LNR and overall survival (OS) and cancer-specific survival (CSS). Based

SUBMITTER: Chen T 

PROVIDER: S-EPMC11760061 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature