Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages.

ABSTRACT:

Background

Leishmaniases are neglected tropical diseases with great clinical and epidemiological importance. The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long treatment time, and parasite resistance. The discovery of new therapeutic alternatives is extremely essential, and the discovery of cellular targets is a tool that helps in the development of new drugs. Serine proteases emerge as important virulence factors in the Leishmania genus, as they participate in important processes involved in their infectivity, virulence, and survival. In this work, we evaluated the leishmanicidal effect of different serine protease inhibitors (Benzamidine, PF-429242, PMSF, TLCK, and TPCK). Additionally, we determ

SUBMITTER: de Almeida Machado P 

PROVIDER: S-EPMC11760092 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature