Nanoparticle Contrast Agents for Dark-Field X-ray Imaging.

ABSTRACT: The poor soft tissue contrast of X-ray CT necessitates contrast agent use to improve diagnosis across disease applications, yet their poor detection sensitivity requires high injected doses, which restrict use in at-risk populations. Dark-field X-ray imaging is emerging as a more sensitive alternative to traditional attenuation-based imaging, leveraging scattered radiation to produce contrast. Yet aside from large, short-lived microbubbles, the alternate physics of dark-field detection has yet to be exploited for contrast agent development. Here we demonstrate that high-Z nanoparticles can provide a new means to producing dark-field image contrast, promoting scatter via a higher rather than lower electron density compared to microbubbles, increasing detection sensitivity compared to attenu

SUBMITTER: Navarrete-Leon C 

PROVIDER: S-EPMC11760164 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature