Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography.

ABSTRACT:

Purpose

To characterize frequency-dependent wave speed dispersion in the human cornea using microliter air-pulse optical coherence elastography (OCE), and to evaluate the applicability of Lamb wave theory for determining corneal elastic modulus using high-frequency symmetric (S0) and anti-symmetric (A0) guided waves in cornea.

Methods

Wave speed dispersion analysis for transient (0.5 ms) microliter air-pulse stimulation was performed in four rabbit eyes ex vivo and compared to air-coupled ultrasound excitation. The effects of stimulation angle and sample geometry on the dispersion were evaluated in corneal phantoms. Corneal wave speed dispersion was measured in 36 healthy human eyes in vivo.

Results

Air-pulse-induced dispersion was comparable to ultrasound-induced dis

SUBMITTER: Duvvuri C 

PROVIDER: S-EPMC11760281 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature