Intratympanic administration of dexamethasone attenuates radiation induced damage to middle ear mucosa.

ABSTRACT: Radiotherapy (RTx) is a highly effective treatment for head and neck cancer that can cause concurrent damage to surrounding healthy tissues. In cases of nasopharyngeal carcinoma (NPC), the auditory apparatus is inevitably exposed to radiation fields and sustains considerable damage, resulting in dysfunction. To date, little research has been conducted on the changes induced by RTx in the middle ear and the underlying mechanisms involved. Dexamethasone (DEX) is widely used in clinical practice because of its immunosuppressive and anti-inflammatory properties. The present study investigated the effects and underlying mechanisms of DEX delivered via intratympanic administration on RTx-induced damage to the middle ear and human middle ear epithelial (HMEE) cells. Sprague-Dawley (SD) rats were

SUBMITTER: Kwon HC 

PROVIDER: S-EPMC11760350 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature